Which patient profile increases OHSS risk?

• A. Older age with high BMI and low hormones
• B. Young age, PCOS, low BMI, high AMH/estradiol
• C. Middle age with normal BMI
• D. Postmenopausal

Answer: (B)

OHSS risk rises with markers of high ovarian response to stimulation. Young age often means a larger pool of recruitable follicles, and PCOS further amplifies ovarian responsiveness due to abundant antral follicles. High AMH indicates a high ovarian reserve, and high estradiol reflects many developing follicles releasing estrogen. Low BMI can increase sensitivity to gonadotropins and elevate circulating hormone levels, further elevating OHSS risk. So a young patient with PCOS, low BMI, and high AMH/estradiol best fits the profile associated with higher OHSS risk. In contrast, older age with high BMI and low hormones suggests reduced ovarian response and lower risk, middle age with normal BMI has intermediate risk, and postmenopause has minimal ovarian activity, making OHSS unlikely.